Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria
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چکیده
منابع مشابه
Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria.
Hemoglobin E is very common in parts of Southeast Asia. The possible malaria protective effects of this and other inherited hemoglobin abnormalities prevalent in Thailand were assessed in a mixed erythrocyte invasion assay. In vitro, starting at 1% parasitemia, Plasmodium falciparum preferentially invaded normal (HbAA) compared to abnormal hemoglobin (HbH, AE, EE, HCS, beta-thalassemia E) red c...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria
Hemoglobin E is very common in parts of Southeast Asia. The possible malaria protective effects of this and other inherited hemoglobin abnormalities prevalent in Thailand were assessed in a mixed erythrocyte invasion assay. In vitro, starting at 1% parasitemia, Plasmodium falciparum preferentially invaded normal (HbAA) compared to abnormal hemoglobin (HbH, AE, EE, HCS, -thalassemia E) red cells...
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BACKGROUND The role of volume resuscitation in severe Plasmodium falciparum malaria is controversial. AIM To examine the role of hypovolaemia in severe childhood malaria. STUDY DESIGN Retrospective review. METHODS We studied 515 children admitted with severe malaria to a high-dependency unit (HDU) in Kilifi, Kenya. On admission to the HDU, children underwent a further assessment of vital ...
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ژورنال
عنوان ژورنال: Blood
سال: 2002
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v100.4.1172.h81602001172_1172_1176